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Home > Chemical product channel > 491-67-8 baicalein (491-67-8)

Identification of 491-67-8

Name:baicalein

CAS No.:491-67-8

Molecular Weight: 270.23700

Formula: C15H10O5

Synonyms: 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-phenyl-; 5,6,7-TRIHYDROXYFLAVONE; 4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL; 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one; Baicalein; Noroxylin; Baicalin; Baicelein;

Safety Data

Safety Statements: 26-36

Properties

Vapour:8.55E-18mmHg at 25°C

Flash Point:225.2ºC

Appearance:Yellow Crystalline Solid

Density:1.548 g/cm3

Melting Point:264-265ºC

Boiling Point:575.9ºC at 760 mmHg

Storage temp:2-8ºC

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    Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum or Indian trumpetflower. It is the aglycone of baicalin. Baicalein is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement believed to enhance liver health.Baicalein, along with its analogue baicalin, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors. In accordance, baicalein shows anxiolytic effects in mice without incidence of sedation or myorelaxation. It is thought that baicalein, along with other flavonoids, may underlie the anxiolytic effects of S. baicalensis and S. lateriflora. Baicalein is also an antagonist of the estrogen receptor, or an antiestrogen. The flavonoid has been shown to inhibit certain types of lipoxygenases and act as an anti-inflammatory agent. It has antiproliferative effects on ET-1-induced proliferation of pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression. Possible antidepressant effects have also been attributed to baicalein in animal research. Baicalein is an inhibitor of CYP2C9, an enzyme of the cytochrome P450 system that metabolizes drugs in the body.A derivative of baicalin is a known prolyl endopeptidase inhibitor. Baicalein has been shown to inhibit Staphylococcus aureus biofilm formation and the quorum sensing system in vitro.

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  • ADVANCED TECH. & IND. CO., LTD.

     Hong Kong,Hong Kong SAR(China)

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  • 5,6,7-Trihydroxyflavone

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  • Applichem GmbH

     Darmstadt,Germany

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    Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum or Indian trumpetflower. It is the aglycone of baicalin. Baicalein is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement believed to enhance liver health.Baicalein, along with its analogue baicalin, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors. In accordance, baicalein shows anxiolytic effects in mice without incidence of sedation or myorelaxation. It is thought that baicalein, along with other flavonoids, may underlie the anxiolytic effects of S. baicalensis and S. lateriflora. Baicalein is also an antagonist of the estrogen receptor, or an antiestrogen. The flavonoid has been shown to inhibit certain types of lipoxygenases and act as an anti-inflammatory agent. It has antiproliferative effects on ET-1-induced proliferation of pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression. Possible antidepressant effects have also been attributed to baicalein in animal research. Baicalein is an inhibitor of CYP2C9, an enzyme of the cytochrome P450 system that metabolizes drugs in the body.A derivative of baicalin is a known prolyl endopeptidase inhibitor. Baicalein has been shown to inhibit Staphylococcus aureus biofilm formation and the quorum sensing system in vitro.

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    Quality & Price 1. Factory price, reliable quality 2. Years produce and exporting experience 3. Strict quality control, all products are traceable 4. Advanced technology and equipments, strong R&D ability 5. Free sample for test before order available, 100% test before shipment Service 1. Enough stock, fast shipment, professional team to handle it 2. Different packing can be customized, photos available before shipment 3. Quick response for all inquiries or claims 4. Flexible MOQ for different demand 5. Different payment methods available Based on strong R&D ability, advanced production technology and experienced team; pluses international trade office in Wuhan, we can offer high and stable quality products with quick response and service. Please contact us freely for more details about products specification, packing method, price term, lead time, payment term and any other information, we would try our best to satisfy you both on quality and price as much as we can.

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