Folate is one of the B vitamins and also a water-soluble vitamin. The daily intake of folate from foods or dietary supplements is recommended 400 micrograms according to the US. The study shows that folic acid is particularly important for women during pregnancy. Folic acid is used as a supplement to prevent neural tube defects in the baby.
Folic acid can promote the maturation of bone marrow cells, folic acid deficiency can cause megaloblastic anaemia and leukopenia.
There are many foods that contain folic acid, but the natural folic acid is very unstable and easy to be affected by the sun and heating to oxidation. So the folic acid absorption by human body from food is not much. The bioavailability of folic acid is low, which is about 45%. The synthesis of folic acid can keep stable in a period of months or years, and can be easily absorbed and utilized by human body.
The biological factor was first isolated via extraction from spinach leaves in 1941, therefore it was named folic acid. This vitamin B9 is rich in fresh fruits, vegetables, and meat products. 50% to 90% folic acid may be lost during long time of food cooking.
The absorption is mainly in duodenum and proximal jejunum. Its storage in human body is 5 ~ 20mg. Folic acid is excreted mainly through urine and feces, and the daily output is 2 - 5ug.
MTHFR is an important enzyme involved in the cyclic metabolism of folic acid. It is related to the synthesis of methylation in DNA. This B vitamin is an indispensable component of cell division and synthesis of DNA. In 60s, researchers did animal experiments and found that folic acid deficiency could cause neural tube defects. Therefore, MTHFR gene detection can guide pregnant women to reasonably supplement folic acid, and prevent cleft lip and palate, down syndrome, neural tube defects and other birth defects. It suitable for normal couples of prenatal testing.
Folic acid has become a new health vitamin product on the international market after vitamin C and vitamin E, and its market prospect is very broad. Iron folic acid is one of these products.