Get to know calcium folinate
Calcium folinate is a white to yellowish crystalline
or amorphous powder, which is odourless, and dissolved in water but insoluble
in ethanol or ether. Calcium folinate is always used to counteract therapeutic
and toxic effects of folic acid antagonists, enhance therapeutic and toxic
effects of fluoropyrimidines used in cancer therapy and sometimes used as
supplements folic acid in folic acid deficiency.
Functions of calcium folinate
Calcium folinate can be used in either tablets or injection, which is applicable in
the following indications:
Colorectal cancer and gastric
Calcium folinate can combine with uracil to improve the efficacy of fluorouracil, which is often used in the treatment of colorectal cancer and gastric cancer.
2) To reduce toxicity and counteract effects of impaired methotrexate elimination or inadvertent overdose of folic acid antagonist
As an antidote to folate antagonists
such as methotrexate, pyrimidine or trimethoprim, calcium folinate is often
used to prevent severe toxic effects caused by overdose of methotrexate.
Megaloblastic anemia secondary
to folic acid deficiency
When oral folic acid is not effective,
it is also used for oral diarrhea, malnutrition, macrocytic anemia during
pregnancy or infancy, but not for vitamin B12 deficiency anemia.
of using calcium folinate
Calcium folinate shall be used cautiously in children, pregnant or breatfeeding
patients, patients with anemia (when vitamin B12 deficiency has been ruled our)
or patients receiving 5-FU concomitantly. Use the product as prescribed.
reactions after using the calcium folinate
Though it is rare, and it occasionally
causes rashes, urticaria, or other allergic reactions such as asthma.
to buy the quality calcium folinate
There are many verified supplier members of
pharmaceutical raw materials on OKCHEM, a leading B2B platform for chemical
business, and we also find one of our verified supplier, Zhejiang Davi
Pharmaceutical Co., Ltd, is supplying quality calcium folinate products.
Established in 2004, Zhejiang DaviPharmaceutical Co., Ltd is a foreign-funded GMP approved drug manufacturer,
which dedicates in R&D, manufacture and sales of APIs and additives. Major
products of the supplier include folic acid, calcium folinate(leucovorin calcium),calcium
levofolinate, methotrexate, methotrexate sodium, levofolinic acid,cytarabine.
Click here to inquire.
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