What is amoxicillin and clavulanate potassium?
Amoxicillin clavulanate is a compound preparation consisting of 0.5 gram amoxicillin and 0.125 gram clavulanic potassium per tablet.
Amoxicillin is one of the most commonly used semi-synthetic penicillin-based and broad spectrum beta-lactamase antibiotics which often comes in the form of white powder with a half-life of about 61.3 minutes. It is stable under acidic conditions with the gastrointestinal absorption rate of 90%. Amoxicillin has a strong bactericidal function and a powerful ability to penetrate the cell membrane, so it is one of the most widely used synthetic penicillin. The preparation can come in the forms of capsules, tablets, granules, dispersible tablets,etc and now it is often used with clavulanate potassium to make dispersible tablets .
Clavulanate potassium is a kind of white or yellowish crystalline powder with a slight odor and strong moisture absorption which is easy to dissolve in water, soluble in methanol, slightly soluble in ethanol and insoluble in ether. It is ineffective when used alone and often used in combination with penicillin drugs for microbial drug resistance and improve the efficacy.
Amoxicillin clavulanate potassium is an oval-shaped film-coated tablet with a recessed 'AC' and a scribe line on one side and a smooth finish on the other side. It is white after removing the coating.
What is amoxicillin and clavulanate potassium tablets used for?
Amoxicillin and clavulanate potassium can be used twice a day for short-term treatment of the following infections
Upper respiratory tract infection such as: tonsillitis, sinusitis, otitis media.
Lower respiratory tract infections such as: acute and chronic bronchitis, lobar pneumonia and bronchial pneumonia.
Reproductive urinary tract infections such as: cystitis, urethritis, pyelonephritis.
Skin and soft tissue infections: boils, abscesses, cellulitis, traumatic infections.
Bone and joint infection: osteomyelitis.
Other infections such as: infective abortion, pelvic infection and abdominal infection.
What side effects does amoxicillin and clavulanate potassium have?
1, Gastrointestinal reaction such as diarrhea, nausea and vomiting.
2, Rashes, especially for people withinfectious mononucleosis
3, Visible allergic shock, drug fever and asthma.
4, Occasional elevated serum transaminase, eosinophilia, leukopenia and secondary infection caused by Candida or drug-resistant bacteria.
Precautions for use amoxicillin and clavulanate potassium
Amoxicillin and clavulanate potassium is a penicillin antibiotic, so a skin test is necessary before use. This product has antibacterial effect on Gram-positive bacteria such as meningococcus, Bacteroides, Clostridium, Bacillus, Clostridium, Digestive Streptococcus, Streptococcus, Streptococcus, etc. But Cassilin is mainly used for anti-Gram-negative bacteria, so this product is generally not used for the simple infection caused by these bacteria.
Amoxicillin and clavulanate potassium usage and dosage