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CAS No.:2682-20-4
Molecular Weight: 115.15400 Molecular Formula: C4H5NOS


Methylisothiazolinone, MIT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications. It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and is proving to be a concern because of sensitization and allergic reactions as well as cell and nerve damage. Industrial manufacturing and distribution of the biocide has resulted in more severe health hazards to the humans involved in the handling of large concentrated quantities of the biocide. Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.


Appearance:White to yellow powder
Density:1.25 (14% aq.)
Melting Point:254-256ºC
Boiling Point:182.8ºC at 760 mmHg
Storage temp:
Vapour:<0.1 mm Hg ( 25 °C)
Refractive Index:
Flash Point:64.3ºC

Safety and Handling

RTECS:UN 3077 9/PG 3

Hazard Class:III

Safety Statements:S24-S26-S36/37/39-S60-S61

HS Code:2934100090

Packing Group:III

WGK Germany:2

RIDADR:UN 3077 9/PG 3

Risk Statements:R20/21/22; R34; R43; R50

Hazard Codes:C

Signal Word:Danger

Symbol:GHS05, GHS06, GHS09

Caution Statement:P261; P273; P280; P305 + P351 + P338; P310

Hazard Declaration:H302; H314; H317; H331; H335; H400

NMR Spectrum