FlibanserinSynonyms:3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one;Filbanserin;Flibanerins;1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-oneCAS:167933-07-5Flibanserin MF: C20H21F3N4OFlibanserin MW:390.4Appearance: White powderPurity: 99%Flibanserin Introduction:HSDD is the most commonly reported form of female sexual dysfunction. HSDD is defined as a persistent or recurrent deficiency or absence of sexual fantasies and desire for sexual activity that causes marked distress or interpersonal difficulty, and which is not better accounted for by a medical, substance-related, psychiatric (e.g., depression) or other sexual condition. The cause of HSDD is believed to involve a multitude of social, psychological and biological factors and may be attributed to a complex interplay of these factors. Flibanserin is a novel, non-hormonal drug that has been studied in clinical trials for the treatment of HSDD in premenopausal and postmenopausal women. The application submitted to the FDA is for premenopausal women. Flibanserin is believed to work on key neurotransmitters, or chemicals, in the brain that affect sexual desire. More specifically, it is thought that flibanserin corrects an imbalance of levels of these neurotransmitters by increasing dopamine and norepinephrine (both responsible for sexual excitement) and decreasing serotonin (responsible for sexual inhibition). In clinical studies, flibanserin was evaluated for its ability to increase the frequency of satisfying sexual events, increase the intensity of sexual desire and decrease the associated distress women feel from its loss. Items Specification pH 3.5-4.5 Identification 1, red to dark purple color appears with(III)iron chloride 2, light red precipitate formed with reinecke salt TS 3, UV spectrum meet the reference 4, solution (1%) responds to the qualitative test for chloride Melting point 139-143℃ Clarity and color of solution Clear and colorless Sulfate 0.048%max Heavy metals 10ppm max As 2ppm max Organic acid(0.1M NaOH) 0.54ml max Loss on drying 0.5% max Residue on ignition 0.1%max Residual organic Solvents (GC) Xylol 0.217%max Isopropanol 0.5%max Related substances(HPLC) Total impurity 1.5%max Single impurity0.5%max Free P-chloro phenoxy acetic 0.5%max Count of bacteria bacillus 1000/1g max Mildew 100/1g max Microzyme 100/1g max Assay(C12H16CINO3.HCl,on dry basis) 98%min Flibanserin Dosage Recommand: Flibanserin Dosage Recommended dosage is 100 mg taken once daily at bedtime. Taking it at night reduces the risk of sleepiness, low blood pressure, and fainting during waking hours If your symptoms do not improve after 8 weeks of treatment, stop treatment and call your doctor. If a dose is missed at bedtime, take the next dose at bedtime the following day. Do not take a double dose to make up for a missed one.