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Monosodium Glutamate Anhydrous
20 MT
India
3,3-Dimethyl-1-Butanol
300 G
United States
100% Virgin Bottle grade PET resin chips
300 MT
United States
Sunflower oil
5 MT
Tunisia
2-(chloromethyl)oxirane
1 KG
Malaysia
PREMIX POWDER FOR MOSQUITO COIL MANUFACTURING - ALL POWDERS USED IN MOSQUITO COIL MANUFATURING
100 MT
United Kingdom
3-Methylbenzoic acid
50 MT
India
UREA AMMONIUM NITRATE
10000 MT
South Africa
Tetracaine Base
1 20' Container
Brazil
Pharmaceutical intermediates 1-Benzyl-5-phenylbarbituric acid 72846-00-5
1 MT
China
Rice Protein 80%
1 MT
Mexico
Ethylenediaminetetraacetic acid tetrasodium salt, tetrahydrate
2 20' Container
Vietnam
Injection Grade Recycled PP
100 MT
India
SLES 70%
22 MT
Mexico
LABSA
22 MT
Mexico
Sodium Hydroxide CAS 1310-73-2
2 MT
Mongolia
Sodium Lauryl Ether Sulfate (SLES) CAS 68585-34-2
2 MT
Mongolia
Sodium metasilicate nonahydrate CAS 13517-24-3
2 MT
Mongolia
SMBS
1 40' Container
South Africa
Fluorite
Brazil
-10.4%
$ 130.00 /KG $ 145.00/KG
-15.4%
$ 55.00 /KG $ 65.00/KG
-5.2%
$ 46.50 /KG $ 49.00/KG
-1.2%
$ 168.00 /KG $ 170.00/KG
-33.4%
$ 16.00 /KG $ 24.00/KG
Singapore City,Singapore
2019.06.25 - 2019.06.26
Ho Chi Minh City,Vietnam
2019.06.26 - 2019.06.28
Ho Chi Minh City,Vietnam
2019.06.26 - 2019.06.28
Bogota,Colombia
2019.07.11 - 2019.07.21
São Paulo,Brazil
2019.08.20 - 2019.08.22
Shanghai,China
2019.08.28 - 2019.08.30
Shanghai,China
2019.08.28 - 2019.08.30
Bangkok,Thailand
2019.09.11 - 2019.09.13
For its 100th anniversary, the International Union of Pure and Applied Chemistry (IUPAC) announced the top ten emerging technologies in chemistry that will change the world, and one of them is the nanopesticide. It’s noticed that nano-pesticide has again become a hot topic in the chemical industry owing to the fact that the pollution of traditional pesticide on our farmlands has endangered the health of human beings. Recently, it’s reported that more than 100 pesticides have been revealed in Europe's rivers and canals including 24 not licensed for use in the EU. And another news that a kind of weedkiller from a German pharmaceutical giant caused man’s cancer also shocked the world. All of such news revealed that it’s necessary for us to think about the pros and cons of traditional pesticides as well as its negative influence on our planet. At present, China has already become the world's largest producer and consumer of pesticides. The annual chemical control area is about 7 billion mu and over 2 million tons of pesticides are used. China’s Pesticides Export Weight in 2014-2018 (Data source: Institute for the Control of Agrochemicals, Ministry of Agriculture) In 2014, the export of pesticides from China was 1,721,300 tons, totaling 9.198 billion US dollars, marking the highest record in China's pesticide exports. In 2018, 1,405,400 tons of pesticides have been exported, down by -13.5% year-on-year, while the export value amounted to 8.073 billion US dollars, seeing a +8.6% year-on-year growth. And the pesticides from China have been exported to more than 170 countries and regions all over the world. Distribution of Pesticide Exports in 2018 (Data source: Institute for the Control of Agrochemicals, Ministry of Agriculture) The pesticides in China were mainly exported to Asia, accounting for 31% of the total exports of pesticides in 2018, followed Latin America and Africa with the proportion of 27% and 17% respectively. China feeds 22% of the world's population with only about 7% of the world's arable land. The role of pesticides in defending against major biological disasters and ensuring food security in China is undoubtedly indispensable. At present, chemical control is still an irreplaceable technical means to prevent major biological disasters. However, the pesticide residue pollution has always been a major problem that plagues China's agricultural production and food safety. Traditional pesticides have many defects, such as large drug-loading particles, poor dispersion, poor stability, low biological activity, and slow degradation. The utilization rate of target crops is less than 30%, and the amount of dosage to harmful organisms is less than 0.1%. According to statistics, during spraying, the loss of chemicals caused by falling drops, dust drifting, and rain washing is as high as 70%. In addition, the long-term and inefficient application of pesticides has led to many serious problems. For example, pesticide residues in food, vegetables, fruits, and soils and waters in many areas of China have seriously exceeded the standard, which not only poses a serious threat to biological and human health, but also leads to the destruction of ecosystem structure and function. As it is known, nanotech has developed rapidly and has penetrated into various fields such as chemical industry, medicine, energy, materials and life sciences, which has a profound impact on people's lives. The relevant results show that nano-pesticide preparations can significantly enhance the efficacy, prolong the duration, improve the bioavailability, eliminate harmful solvents and additives, thereby greatly reducing the amount of pesticides and reducing agricultural residues and environmental pollution. All in all, despite that there are many concerns about the negative effects and unknown risks of nano-pesticides, it still has a promising future and deserves our expectations.
In its report, “Phenolic Resins Market Size, Share & Trends Analysis Report By Application (Laminate, Molding, Insulation, Wood Adhesive, Paper Impregnation, Coating), By Product (Resol, Novolac), By Region, And Segment Forecasts, 2019 – 2025,” Grand View Research valued the global phenolic resins market size at $11.14 billion in 2018. The global phenolic resin market is expected to register a CAGR of 5.3% over the forecast period. The market is anticipated to be driven by the rapid growth of the end-use industries including consumer electronics, construction, and automotive. Phenolic resins are oligomers, which are formed on repeatedly linking phenolic monomers with aldehyde chemicals. The global market is anticipated to be driven by the development of unique impregnated materials, such as laminates, fabrics, and oil & fuel filters, along with expanding wood adhesive applications that are presenting new avenues for growth across the globe. Rising preference for phenolic laminates owing to their properties including structural strength, moisture-resistance, and high dielectric strength is expected to boost product demand further. The automotive industry is among the key end users, where the phenolic resins are widely used in the raw materials for both interior and exterior components. However, volatility in raw material prices and limitations pertaining to formaldehyde emissions may hinder market development. For instance, in October 2018, the final amendments of National Emission Standards for Hazardous Air Pollutants (HAP): Manufacture of Amino/Phenolic Resins Risk and Technology Review Reconsideration were announced. The amendment aimed at reducing organic HAP emissions from major sources, such as formaldehyde, methanol, phenol, xylene, and toluene. Wood adhesives application accounted for the largest share of 28.0%, in terms of volume, in 2018. The bonding ability of phenolic resins with wood materials and their resistance towards moisture, makes them applicable for outdoor applications in high humidity areas. Molding application holds significant importance in the global market due to increasing growth of the end-use industries. Phenolic molding compounds provide design flexibility and help in achieving weight reduction and cost savings. Due to this, these are used in home appliances and transportation industries Coatings application is anticipated to expand at a CAGR of 5.2% from 2019 to 2025, in terms of revenue, owing to increasing demand for high-performance coatings. Manufacturers focus on new product development to cater to the growing demand for eco-friendly products. For instance, in April 2017, Hexion Inc. introduced new Bakelite phenolic resin with ultra-low-free-formaldehyde content for coatings. It has less than 0.1% formaldehyde content and free phenol levels below 0.5%. These are specifically designed for anticorrosive and powder coatings. Asia Pacific held the largest revenue share in 2018 and is estimated to expand further at the highest CAGR over the forecast years. In 2018, North America was the second-largest contributor to the market with a revenue share of 34.5% in 2018. Source: inkworldmagazine.com
The production processes of the most important basic chemicals are responsible for around 70 percent of the greenhouse gas emissions in the chemical industry. BASF experts are working intensely on new technologies to substantially reduce emissions in these processes. The company has bundled all of this work under the roof of its ambitious Carbon Management Program. One of the first visible successes in this area has been achieved by a project team which has applied to patent a process to produce methanol without any greenhouse gas emissions. If it can be successfully implemented at an industrial scale, the entire production process – from syngas production to pure methanol – will no longer release any carbon dioxide emissions. Typically, methanol is made from syngas, which until now has been primarily obtained from natural gas via a combination of steam and autothermal reforming. Using special catalysts, this can then be turned into crude methanol, which can be further processed after purification. In the new BASF process, the syngas is generated by partial oxidation of natural gas, which does not cause any carbon dioxide emissions and has proven to be advantageous in a study jointly conducted with Linde Engineering. The subsequent process steps – methanol synthesis and distillation – can be carried out nearly unchanged. Ingenuity was required to address the merging and processing of the waste gas streams that arise during methanol synthesis and distillation and which cannot be avoided even with optimal process management. These waste gas streams consisting of methane, carbon monoxide, carbon dioxide and hydrogen are incinerated in an Oxyfuel process with pure oxygen. This results in a small volume of flue gas with a maximum carbon dioxide content. The flue gas is then scrubbed using BASF’s OASE process for the full recovery of the carbon dioxide. To ensure that the carbon contained in the carbon dioxide is not lost and that it can be used again for methanol synthesis, the captured carbon dioxide is fed back into the beginning of the process. This does, however, require additional hydrogen, which BASF also aims to produce without any carbon dioxide emissions, for example, via methane pyrolysis, which is also being developed in the Carbon Management research program. “We are optimistic that our climate-friendly approach will better adapt methanol synthesis to the requirements of the 21st century,” said project manager Dr. Maximilian Vicari from BASF’s Intermediates division. “Nearly 100 years after the first industrial-scale production of this important basic chemical using BASF’s high-pressure process, we are now taking a leading role in writing the newest chapter in the history of methanol.” Vicari expects it will be around 10 years before this new process is carried out in an industrial-scale plant. Source: coatingsworld.com
University of Colorado — LookingVibrant is a young company providing premier dietary supplements with maximum health bene?ts without the use of chemicals or Chinese ingredients. By now, we have all heard about the lawsuit by the New York Governor against supplements sold in major retailers; finding that four out of five supplements didn’t contain any of the ingredients that were listed on the labels. LookingVibrant has developed formulas with all-active ingredients including transporters/delivery systems – in capsules and liquid – that help escort phytochemicals to the intended targets inside your body. LookingVibrant offers Liposomal Supplement Formulas that don’t just beat traditional supplements but are also superior to any liposomal products in the world, in areas of bioavailability and quality. Formulas have been incorporated into a range of chemical-, soy-, gluten-, alcohol-, BPA-, MSG- and EDTA-free products delivering antioxidants that support digestive, reproductive, neuro, and heart health, as well as overall wellness. Our new breakthrough Liposomal Products optimize nutrient delivery to maximize potency A clinical trial involving students from the University of Colorado aimed to detect the presence of antioxidants in the participants’ bloodstream after testing the bioavailability of green tea with LookingVibrant’s Lipid Capsule Technology as a delivery method. The liposomal creators found a significant amount of green tea EGCG in the students’ bloodstream 45 minutes after they had consumed the lipid/liposomal green tea formula, as seen in the chart below. EGCG (epigallocatechin gallate) is a potent antioxidant found in green tea known for its potential cancer chemopreventive properties. LookingVibrant was also inspired to conduct experiments involving the delivery of vitamin C after learning about how Liposomal Vitamin C revived a gravely ill New Zealand farmer who had fallen into a coma for weeks. The hospital was about the pull the plug after they had used nearly every medical treatment possible to save his life, but nothing worked. LookingVibrant’s liposomal formulas ensure that all nutrients, including vitamin C, are properly delivered into the bloodstream. According to Dr. Alec Banham from Cambridge, U.K., “Liposomal vitamin is packaged like a bodily cell so it passes through the digestive barrier and delivers more than 90 percent of the nutrients directly to the bloodstream within minutes.” LookingVibrant’s liposomal is derived from non-GMO certified sunflower oil made in Europe and wrapped with a nitrogen blanket to protect from any contamination, from inception to production. Following the merger of LookingVibrant and GENOMX23, the company has grown significantly and meaningfully. Among the latest supplements making waves is the BONE+OSTEOX1000, chemically validated via FTIR finger-printed with Bioperine. Other formulas from the company cover cardiovascular support, digestive health, mobility and motion, herbal estrogen enhancers, probiotic natural testosterone enhancers, CoQ10 Zero Crystal, Extra virgin Norwegian Salmon oil (raw, not CO2 extracted or distilled) and overall health supplements. The company’s products are made in GMP-/FDA-approved facilities in the U.S., undergo rigorous testing, benefit from top phospholipid experts, pharmacognosy specialists and holistic healthcare practitioners. source: antioxidants.news
Melicope lunu-ankenda (ML), also known as Euodia lunuankenda, is a member of the citrus family Rutaceae. It is a shrub native to tropical Asia and is used for food and medicine in many countries. In a recent study published in the Journal of Herbal Medicine, researchers from the Universiti Putra Malaysia examined this plant to determine its medicinal properties. Their findings revealed that it has antioxidant, antidiabetic, and anticancer properties. The genus Melicope in traditional medicine ML is a plant that belongs to the genus Melicope. It grows in dense forests, well-drained areas, and on swampy soils. The wood of ML is soft and weak, but it is still used in construction for paneling and moldings, and for manufacturing plywood. The leaves and flowers of ML, on the other hand, are believed to treat menstrual disorders like amenorrhea and fever, while its roots are commonly used to treat colds and rheumatism. In Malaysia, the leaves of ML are used not only as a condiment but also as a medicine to revitalize the body. Malaysians also use its flowers to treat hypertension and diabetes. In India, ML is known to improve the complexion and stimulate blood flow in the pelvic area, so women commonly use it as an emmenagogue. In some parts of the country, the decocted root of ML is mixed with black pepper and salt to treat asthma and bronchitis. In China, the fruits of Evodia rutaecarpa, a cousin of ML, is used to treat headaches and dysentery. In Vietnam, another cousin of ML, Melicope ptelefolia, is used to treat inflammatory conditions. Other plants from the genus Melicope, like Melicope elleryana, are used to treat infections like malaria in Papua New Guinea while Melicope triphylla is used to treat tuberculosis. (Related: Scientists look at a widely-used herb in Asia as a potential cancer treatment.) Leaf extract from M. lunu-ankenda increases glucose uptake and kills cancer cells For their study, Malaysian researchers used two different cell lines, 3t3-L1 adipocytes and HepG2 hepatocarcinoma cells. 3t3-L1 adipocytes are fat cells derived from mice, while HepG2 is a human liver cancer cell line. Using ferric reducing antioxidant power (FRAP) assay, they found that the 60 percent ethanolic ML extract had high antioxidant activity. That same extract also contained phenolic compounds and flavonoids. To determine if the ML extract has antidiabetic potential, they used 2-NBDG, a fluorescent indicator, to measure glucose uptake in the two cell lines. They found a dose-dependent increase in glucose uptake after ML extract treatment, suggesting that it could affect the insulin sensitivity of cells. The ML extract also proved to be highly cytotoxic against HepG2 but not against 3t3-L1 adipocytes, demonstrating its ability to selectively kill only cancer cells but leave normal cells unaffected. A different study reported that a molecule called O-prenylated flavonoid isolated from the leaves of ML is associated with the plant’s antidiabetic activity. p–O-geranylcoumaric acid, a derivative of p-coumaric acid, is said to be the major compound present in ML leaf extracts. The antioxidant activity of ML, on the other hand, is attributed to a compound called leptonol. Leptonol and another compound called evodione exhibit anti-inflammatory activity, which explains why ML is traditionally used to treat fever and other inflammatory conditions. As for its anticancer activity, coumarins like melilunumarin A, 6-deoxyhaplopinol, and marmesin are said to contribute to this effect. All three compounds exhibit chemopreventive and anti-proliferation potential against cancer cells in vitro. Their half maximal inhibitory concentration values are also reported to be comparable to curcumin. These findings demonstrate that ML is a medicinal plant that can be used to treat cancer and diabetes. source: antioxidants.news
The Republic of Uzbekistan and Germany have announced plans to construct a new chemical complex for the increased production of fertilizers in Samarkand, Uzbekistan. The plant will be built on an are of the Samarkand region owned by JSC Samarkandkimyo, and that potential output at the complex will include: ammonium sulfate, urea, melamine and phosphorous-based fertilizers. It is anticipated that the output will be used domestically, with the option for increased exports. International expertise is provided by thyssenkrupp Industrial Solutions (tkIS), part of the German multinational - thyssenkrupp. The leading investor is Ferkensco Management Ltd. The presidential initiatives support greater synergy between the oil and gas and agriculture sectors, and the use of a specific quality of domestic gas for fertilizer production. The petrochemical industry and fertilizers have an important role to play in boosting Uzbekistan’s economy in the future. The petrochemical industry and fertilizers have vital strategic role in supporting the new Uzbekistan. It is equally important to attract international expertise and capital to support the country’s efforts in these areas. Today’s announcement is a significant step for the country and follows the initiatives outlined by President Shavkat Mirziyoyev. source: worldfertilizer.com
The U.S. Food and Drug Administration approved Piqray (alpelisib) tablets, to be used in combination with the FDA-approved endocrine therapy fulvestrant, to treat postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer (as detected by an FDA-approved test) following progression on or after an endocrine-based regimen. The FDA also approved the companion diagnostic test, therascreen PIK3CA RGQ PCR Kit, to detect the PIK3CA mutation in a tissue and/or a liquid biopsy. Patients who are negative by the therascreen test using the liquid biopsy should undergo tumor biopsy for PIK3CA mutation testing. “Piqray is the first PI3K inhibitor to demonstrate a clinically meaningful benefit in treating patients with this type of breast cancer. The ability to target treatment to a patient’s specific genetic mutation or biomarker is becoming increasingly common in cancer treatment, and companion diagnostic tests assist oncologists in selecting patients who may benefit from these targeted treatments,” said Richard Pazdur, M.D., director of the FDA’s Oncology Center of Excellence and acting director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug Evaluation and Research. “For this approval, we employed some of our newer regulatory tools to streamline reviews without compromising the quality of our assessment. This drug is the first novel drug approved under the Real-Time Oncology Review pilot program. We also used the updated Assessment Aid, a multidisciplinary review template that helps focus our written review on critical thinking and consistency and reduces time spent on administrative tasks.” Metastatic breast cancer is breast cancer that has spread beyond the breast to other organs in the body (most often the bones, lungs, liver or brain). When breast cancer is hormone-receptor positive, patients may be treated with anti-hormonal treatment (also called endocrine therapy), alone or in combination with other medicines, or chemotherapy. The efficacy of Piqray was studied in the SOLAR-1 trial, a randomized trial of 572 postmenopausal women and men with HR-positive, HER2-negative, advanced or metastatic breast cancer whose cancer had progressed while on or after receiving an aromatase inhibitor. Results from the trial showed the addition of Piqray to fulvestrant significantly prolonged progression- free survival (median of 11 months vs. 5.7 months) in patients whose tumors had a PIK3CA mutation. Common side effects of Piqray are high blood sugar levels, increase in creatinine, diarrhea, rash, decrease in lymphocyte count in the blood, elevated liver enzymes, nausea, fatigue, low red blood cell count, increase in lipase (enzymes released by the pancreas), decreased appetite, stomatitis, vomiting, weight loss, low calcium levels, aPTT prolonged (blood clotting taking longer to occur than it should), and hair loss. Health care professionals are advised to monitor patients taking Piqray for severe hypersensitivity reactions (intolerance). Patients are warned of potentially severe skin reactions (rashes that may result in peeling and blistering of skin or mucous membranes like the lips and gums). Health care professionals are advised not to initiate treatment in patients with a history of severe skin reactions such as Stevens-Johnson Syndrome, erythema multiforme, or toxic epidermal necrolysis. Patients on Piqray have reported severe hyperglycemia (high blood sugar), and the safety of Piqray in patients with Type 1 or uncontrolled Type 2 diabetes has not been established. Before initiating treatment with Piqray, health care professionals are advised to check fasting glucose and HbA1c, and to optimize glycemic control. Patients should be monitored for pneumonitis/interstitial lung disease (inflammation of lung tissue) and diarrhea during treatment. Piqray must be dispensed with a patient Medication Guide that describes important information about the drug’s uses and risks. Piqray is the first new drug application (NDA) for a new molecular entity approved under the Real-Time Oncology Review (RTOR) pilot program, which permits the FDA to begin analyzing key efficacy and safety datasets prior to the official submission of an application, allowing the review team to begin their review and communicate with the applicant earlier. Piqray also used the updated Assessment Aid (AAid), a multidisciplinary review template intended to focus the FDA’s written review on critical thinking and consistency and reduce time spent on administrative tasks. With these two pilot programs, today’s approval of Piqray comes approximately three months ahead of the Prescription Drug User Fee Act (PDUFA) VI deadline of August 18, 2019. The FDA granted this application Priority Review designation. The FDA granted approval of Piqray to Novartis. The FDA granted approval of the therascreen PIK3CA RGQ PCR Kit to QIAGEN Manchester, Ltd. Source: drugs.com
Sunscreen is a real key to protecting your skin from the sun and preventing skin cancer, but are you using it correctly? Santa Monica-based dermatologist Dr. Tanya Kormeili thinks not. A recent American Academy of Dermatology (AAD) found "only about a third of Americans are reapplying their sunscreen every two hours while outside. Since sunscreen wears off, incorrect usage leaves you unprotected and susceptible to skin cancer," Kormeili said in an AAD news release. She outlined other common sunscreen mistakes and how to avoid them. First, read the sunscreen labels. You should choose sunscreens that are broad-spectrum, water-resistant and have an SPF of 30 or higher. Second, most people apply only one-quarter to one-half of the recommended amount of sunscreen. To fully cover their body, most adults need about 1 ounce of sunscreen, or enough to fill a shot glass. Apply enough sunscreen to cover all skin that isn't covered by clothing. Apply it 15 minutes before going outdoors, and reapply every two hours while outdoors or after swimming or sweating. Third, only 20% of Americans apply sunscreen on cloudy days, but the sun's harmful ultraviolet (UV) rays go through clouds. Apply sunscreen every time you go outside, even under clouds. Another mistake is using old sunscreen. Sunscreens are required to retain their original strength for at least three years. Throw out your sunscreen if it's expired or you're unsure how long you've had it. If you buy sunscreen that doesn't have an expiration date, write the purchase date on the bottle so that you know when to stop using it. "Sunscreen is the most important skin care product you can use, as it helps prevent sunburn, skin cancer and premature skin aging, including wrinkles and age spots," Kormeili said. "However, to ensure the best protection for you and your family, it's important to follow the manufacturer's directions before using." She added, however, that no sunscreen can block 100% of the sun's UV rays. So even when you use sunscreen, it's also important to seek shade and wear protective clothing, including a lightweight, long-sleeved shirt, pants, a wide-brimmed hat and sunglasses with UV protection. Skin cancer is the most common cancer in the United States, affecting 1 in 5 Americans in their lifetime, according to the AAD. Source: drugs.com
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